Loss of CGRP Reduces Sound-Evoked Activity in the Cochlear Nerve
نویسندگان
چکیده
Stéphane F. Maison, Ronald B. Emeson, Joe C. Adams, Anne E. Luebke, and M. Charles Liberman Department of Otology and Laryngology, Harvard Medical School and Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114; Department of Pharmacology and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232; and Department of Otolaryngology and Neuroscience Program, University of Miami School of Medicine, Miami, Florida 33136
منابع مشابه
Maturation of suprathreshold auditory nerve activity involves cochlear CGRP–receptor complex formation
In adult animals, the neuropeptide calcitonin gene-related peptide (CGRP) is contained in cochlear efferent fibers projecting out to the cochlea, and contributes to increased suprathreshold sound-evoked activity in the adult auditory nerve. Similarly, CGRP applied to the lateral-line organ (hair cell organ) increases afferent nerve activity in adult frogs (post-metamorphic day 30), yet this inc...
متن کاملLoss of α-calcitonin gene-related peptide (αCGRP) reduces the efficacy of the Vestibulo-ocular Reflex (VOR).
The neuroactive peptide calcitonin-gene related peptide (CGRP) is known to act at efferent synapses and their targets in hair cell organs, including the cochlea and lateral line. CGRP is also expressed in vestibular efferent neurons as well as a number of central vestibular neurons. Although CGRP-null (-/-) mice demonstrate a significant reduction in cochlear nerve sound-evoked activity compare...
متن کاملSingle unit recordings in the auditory nerve of congenitally deaf white cats: morphological correlates in the cochlea and cochlear nucleus.
It is well known that experimentally induced cochlear damage produces structural, physiological, and biochemical alterations in neurons of the cochlear nucleus. In contrast, much less is known with respect to the naturally occurring cochlear pathology presented by congenital deafness. The present study attempts to relate organ of Corti structure and auditory nerve activity to the morphology of ...
متن کاملAcoustic Sensitivity of the Saccule and Daf Music
Introduction: The daf is a large Persian frame drum used as a musical instrument in both popular and classical music which can induce a percussive sound at low frequencies (146–290 Hz) with peaks of up to 130 dBspl. The percussive sounds have a power distribution in the region of saccular sensitivity. In view of the saccular stimulation by sound in humans, we decided to use cervical vestibu...
متن کاملEvaluation of the Slope of Amplitude Growth Function Changes of the Electrically Evoked Action Potential in Three Months after Receiving the Device in Children with Cochlear Implant
Objective: In neural response telemetry, intracochlear electrodes stimulate the auditory nerve and record the neural responses. The electrical stimulation is sent to the auditory nerve by an electrode and the resulted response, called electrically evoked compound action potential, is recorded by an adjacent electrode. The most important clinical applications of this test are evaluation and moni...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2003